Yeah... reducing the pipe diameter from 16/22 to 12/16 anywhere along the outlet line would create a huge drop in flow rate, its basically the same effect as adjusting the double taps on a canister filter to reduce flow.
I've tested reducing pipe diameters in canister filters before and found that the flow can drop down 40%-50% lower too. I guess if you can change your pipe back to 16/22, you'll see the flow rate increase back up dramatically.
I remember seeing an ISTA inline reactor that uses a ceramic diffuser + spiral rotor design and it uses 16/22 ports, that could be someting interesting to try with your canister filter.
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