I'm using an eheim subfilter 250 (2213 without motor) connected to an eheim 2213 for my 2ft tank.
For your question, with the eheim double taps with quick release it would be very possible. I used 3 taps myself as it allows myself to clean one filter at a time.
For my case, my setup is Tank---> double tap 1---> 2213 subfilter---> double tap 2---> 2213---> double tap 3---> back to tank
I can close tap 1 and 2 to clean subfilter, and can close 2 and 3 to clean filter.
Not sure if I still have the pictures lying around.
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