You may experience a partial reset in tank cycle after the treatment. The antibiotic kills most of the bacteria, including the one in symbiosis with BGA as well as beneficial ones.
If you have problem within the substrate, it would be wiser to insert broken pills into the problematic areas. By practicing this way instead of dissolving, hopefully bacteria colony esp those outside the inflicted areas such as the filter are mostly spared.
Sometimes I get this BGA problem on the substrate, esp nearby the glass as well even though my tanks are mostly matured. I split 500mg pill into 2-4 parts and insert them. BGA would be slowly gone in a week or so, usually without the need for another course of antibiotic.
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